“When human genome work was wrapping up around 2002, we were discussing what should be next,” JGI’s Uffe Hellsten told BBC News. “At that time there were a couple of furry mammals in the pipeline, and the chicken and at least two fish – but there seemed to be a gaping hole in the branch… [Read More]
The program, said Pati, identifies gene-calling errors such as potentially incorrect gene start and end positions, large overlaps between genes, fragmented genes and missed genes. Gene-calling errors, noted Pati, can range from two percent to as much as 30 percent of the original genes identified in the genome and are dependent on many factors, such… [Read More]
“There are a lot of different tools used for predicting genes in prokaryotes,” Kyrpides said. “The major problem we have is that they all produce very variable results. This impedes our ability to compare genomes sequenced and annotated from various sources, as they use different tools for gene prediction. GenePRIMP is not substituting any of… [Read More]
“With GenePRIMP we have achieved a major breakthrough in the improvement of the quality of structural annotations such as gene predictions,” said Genome Biology Program head and study senior author Nikos Kyrpides. He pointed out that using GenePRIMP offers researchers three major advantages: high quality results with reduced errors; an approach that can be used… [Read More]
Pati said GenePRIMP significantly reduces the amount of time scientists spend checking the whole genome by specifically highlighting errors that need to be manually corrected. Read more on ScienceDaily. [Read More]
More than a thousand microbial genomes have been sequenced at various sequencing centers in the past 15 years to better understand their roles in tasks ranging from bioenergy to health to environmental cleanup. Read more on Medical News Today. [Read More]
To assist in checking the quality of the microbial genomic DNA sequences generated before they are submitted to the federally funded public archive GenBank, the U.S. Department of Energy (DOE) Joint Genome Institute (JGI) has introduced a quality control tool known as the Gene Prediction IMprovement Pipeline or GenePRIMP. GenePRIMP is described in a paper… [Read More]
The Director of the Joint Genome Institute (JGI), Eddy Rubin, has announced that Victor Markowitz will serve as the new Chief Informatics Officer and Associate Director at JGI effective May 17, 2010. Read more on HPC Wire. [Read More]
A new study, published April 30 in Science, lays out the genetic blueprint of the Western clawed frog, Xenopus tropicalis. A larger cousin of X. tropicalis, called Xenopus laevis, is a popular laboratory organism for studying development. But with a genome about half the size of X. laevis’, the Western clawed frog has easier DNA… [Read More]