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August 27, 2021

Boosting Small Molecule Production in Super “Soup”

Yeast strains engineered for the biochemical conversion of glucose to value-added products are limited in chemical output due to growth and viability constraints. Cell extracts provide an alternative format for chemical synthesis in the absence of cell growth by isolating the soluble components of lysed cells. By separating the production of enzymes (during growth) and the biochemical production process (in cell-free reactions), this framework enables biosynthesis of diverse chemical products at volumetric productivities greater than the source strains. (Blake Rasor)Researchers describe a two-pronged approach that starts with engineered yeast cells but then moves out of the cell structure into a cell-free system. [Read More]

August 26, 2021

Virus-Microbe Interactions of Mud Island Mangroves

Ian Rambo, graduate student at UT-Austin, was a DOE Graduate Student Research Fellow at the JGIIan Rambo conducted part of his graduate work at the JGI through the DOE Office of Science Graduate Student Research (SCGSR) program. [Read More]

August 2, 2021

Designer DNA: JGI Helps Users Blaze New Biosynthetic Pathways

(PXFuel)A special issue of Synthetic Biology celebrates research enabled by the JGI DNA Synthesis Science Program. [Read More]

July 28, 2021

A More Intuitive Phytozome Interface

Phytozome portal collageJGI’s plant data portal team highlights the latest Phytozome update while assuring users will continue to have straightforward access to the existing data and features. [Read More]

June 25, 2021

A Natural Mechanism Can Turbocharge Viral Evolution

Virus tail fibers – signified in the cartoon by the blue virus’ downward pointing ‘arms’— don't allow the virus to attach to a purple tinted cell type.A genetic element that enables rapid, targeted mutation is surprisingly widespread and appears to allow viruses to hunt new microbial prey. [Read More]

June 3, 2021

Refining the Process of Identifying Algae Biotechnology Candidates

Algae growing in a bioreactor. (Dennis Schroeder, NREL)A collaborative approach highlights how a screening and characterization pipeline could help accelerate algae biotechnology research efforts. [Read More]

May 20, 2021

Olpidium, The Key to the Origin of Terrestrial Fungi

From Sekimoto et al., 2011: Olpidium bornovanus, a unicellular fungus, is an obligate parasite of plants that reproduces with flagellated, swimming zoospores. A-B. Vegetative unicellular thalli in cucumber root cells. Thalli differentiate into sporangia with zoospores, or into resting spores. C. An empty sporangium, after zoospore release. D. A thick-walled resting spore. E. Zoospores being released from a sporangium, showing the sporangium exit tube (arrowheads). F. A swimming zoospore with a single posterior flagellum. G. An encysted zoospore. Bars: A-E = 10 μm; F,G = 5 μm. (Figures are from Sekimoto et. al., 2011 used under a Creative Commons Attribution 2.0 License.)In this guest blog: a behind-the-paper look at the fungus Olpidium, a link in the evolution and transition of fungi from aquatic to terrestrial habitats. [Read More]

May 11, 2021

Behind the Paper: Hot Springs Metagenomics

Nick Reichart, Montana State University graduate student and 2020 SCGSR fellowMontana State University graduate student Nick Reichart spent a year at the JGI through the DOE Office of Science Graduate Student Research (SCGSR) program. [Read More]

April 30, 2021

Bacteria and Fungi Divvy Up the Work in Forest Floor

The study site in the coniferous forest located in the Bohemian Forest National Park, Czech Republic. (Petr Baldrian)While thousands of species of fungi and bacteria dwell on — and within — the forest floor, who’s recycling the plant biomass? [Read More]

April 28, 2021

Gut Fungi: Unexpected Source of Novel Chemicals

The anaerobic fungus Anaeroromyces robustus growing on reed canary grass. (Vaithiyalingam Shutthanandan, PNNL/EMSL)Combing through the genomes of four anaerobic fungal species has revealed, for the first time, that this group is unexpectedly powerful: they can whip up dozens of complex natural products, including new ones. [Read More]
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