From samples to protein structures and complexes. Center: Researchers gathering samples from Great Boiling Spring in Nevada (Image of Great Boiling Spring by Brian Hedlund, UNLV.). Left: A cartoon of aligned metagenomic sequences. Each row is a different sequence. Each position is compared to all other positions to detect patterns of co-evolution, to predict contacts (yellow line). Top: A contact between two amino acids. Right: Contacts within a protein. Bottom: Contacts between proteins. (Protein structure and composite image by Sergey Ovchinnikov, UW)