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Content Tagged "metagenomics"

Cow rumen metagenome study in Scientific American

“If the industry is going to move forward, it’s going to need new enzymes,” says Eddy Rubin, the director of the U.S. Department of Energy’s Joint Genome Institute. Rubin and 16 colleagues report in the January 28 issue of Science how they discovered nearly 30,000 new enzyme candidates by analyzing DNA collected from a cow’s… [Read More]

Cow rumen metagenome study on EurekAlert

“Microbes have evolved over millions of years to efficiently degrade recalcitrant biomass,” said Eddy Rubin, Director of the JGI and a lead on this study. “Communities of these organisms can be found in diverse ecosystems, such as in the rumen of cows, the guts of termites, in compost piles, as well as covering the forest… [Read More]

Cow rumen metagenome study in This Week in Science

Identification of additional enzymes that can degrade cellulose efficiently should help in the development of biofuels on an industrial scale. Uncultured microorganisms living in cow rumen are highly effective at degrading plant cell walls. Hess et al. used metagenomics and single-genome sequencing to assemble draft genomes from microbes adhering to rumen-incubated switchgrass to identify nearly… [Read More]

DOE JGI’s CSP projects in GenomeWeb Daily News

JGI said its action follows the exponential increase of its sequence output in recent years. Just over the past year, the institute’s sequencing output has leapt to 6 terabytes, up from 1 terabyte at the end of the 2009 fiscal year.“We’re really interested in undertaking projects that either require specific upfront molecular biology, very large… [Read More]

Unpredictable MDA biases in metagenomic analyses

Genomic studies of low-biomass environments is often limited by the amount of DNA available, and one solution has been to use a whole genome amplification technique that uses phi29 DNA polymerase known as multiple displacement amplification (MDA). When used in single cell genomic studies, one noted drawback of the procedure has been amplification bias that… [Read More]

Leaf-cutter ant microbiome breaks down plant biomass

Leaf-cutter ants are community gardeners on a very large scale. Living in colonies composed of several millions, the ants harvest hundreds of kilograms of leaves annually and use them to cultivate fungal gardens that serve as their primary food source. Leaf-cutter ant. (From the October 2010 issue of PLoS Genetics. Image by Jarrod J. Scott,… [Read More]

Syntrophic communities sequencing project on SciGuru

In work published in the advanced online version of the International Society for Microbial Ecology (ISME)’s Journal on August 5, an international team of scientists including DOE JGI researchers report the first metagenome analysis of a microbial community grown in an anaerobic methanogenic (methane producing) bioreactor. The microbial community is syntrophic, i.e., certain organisms live… [Read More]

Terephthalate-degrading consortia

Terepthalate is the byproduct of a common compound used extensively by the plastics industry. The volume of terephthalate wastewater generated is equivalent to the amount of wastewater generated by 20 million people. Syntrophic communities are composed of bacteria that break down organic matter and methanogens that remove the hydrogen released to ensure the degradation process… [Read More]

Tammar wallaby foregut microbiome

Australia and New Zealand were separated from other land masses for millennia, and the unique marsupials found there such as kangaroos and wallabies have forestomachs adapted to efficiently break down lignocellulosic plant mass to extract nutrients. Australian marsupials such as the Tammar wallaby (above) contain unique, uncultured bacteria that could be useful in breaking down… [Read More]

DOE JGI’s role in managing Human Microbiome Project data on redOrbit

At JGI, Kyrpides oversees projects such as GenePRIMP, a highly rated quality control program for genome sequencing, and GOLD, the Genomes On-Line Database. GenePRIMP stands for “Gene PRediction IMprovement Pipeline, and it consists of a series of computational units that can be used to significantly improve the overall quality of the predicted genes in any… [Read More]