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September 7, 2018

Cracking the Code: Evolutionary Changes in the Genetic Code of Yeasts

CUG is translated as Leu in the standard code, and as Ser or Ala in the modified codes. Codons are shown in uppercase. (From Krassowski et al. Evolutionary instability of CUG-Leu in the genetic code of budding yeasts. Nat Commun. doi: 10.1038/s41467-018-04374-7. CC BY 4.0)

Yeasts are some of the most important microbes used in biotechnology. Saccharomyces cerevisiae, the type of yeast used for making bread and beer, is just one representative of more than 1,500 yeast species found around the world. Currently, only a fraction of these yeasts has been harnessed for biotechnological applications. However, researchers studying various “non-conventional”…

September 5, 2018

Defining a Pan-Genome for Antarctic Archaea

Antarctica’s Deep Lake. (Rick Cavicchioli)

Analysis of haloarchaeal metagenomes broadens understanding of Antarctic biogeography. The Science Haloarchaea flourish in hypersaline environments, and researchers are interested in learning how these microbes have learned to adapt from marine to hypersaline conditions by studying the microbial communities in Antarctic lakes, some of which have salinities 10 times that of seawater. To shed light…

August 27, 2018

High Five: Celebrating the JGI-UC Merced Genomics Internship Program

Directly in front of the helix, JGI Director Nigel Mouncey and JGI-UC Merced Genomics Internship founders organizers Axel Visel, Suzanne Sindi and Zhong Wang are flanked by UC Merced student alumni and their JGI mentors.

More than 20 UC Merced students have contributed to the research of 13 JGI scientists since the program’s inception. In 2014, JGI’s Zhong Wang and Science Programs Deputy Axel Visel teamed with University of California (UC), Merced assistant professor Suzanne Sindi from the School of Natural Sciences and started a program that offered a handful…

August 13, 2018

Corymbia Genome Expands Terpene Synthesis Knowledge

Corymbia citriodora subspecies citriodora is a native of north Queensland in Australia but is grown throughout the subtropics for essential oil production. (Photo by Mervyn Shepherd)

Genome annotations of two C. citriodora subspecies broaden understanding of the terpene synthase gene family across eucalypt lineages. The Science From the distinct smell of eucalyptus to the flavor of wine, terpenes are ubiquitous. A diverse group of plant-produced organic compounds, terpenes play key roles in plant growth, defense, and environmental interactions. Terpenes are also…

July 9, 2018

Advancing Awareness of User Science

SSURF 2018 attendees

Berkeley Lab User Facilities Prominent in SSURF Annual Meeting & Capitol Hill Office Visits. Like roads, water and energy systems, ports, and other critical infrastructure, scientific user facilities enable the innovation at the heart of U.S. economic competitiveness and national security. The Society for Science at User Research Facilities (SSURF) is a not-for-profit organization working…

July 6, 2018

Innovative Technology Improves Our Understanding of Bacterial Cell Signaling

The molecule cyclic di-GMP plays a key role in controlling cellulose production and biofilm formation. To better understand cyclic di-GMP signaling pathways, the team developed the first chemiluminescent biosensor system for cyclic di-GMP and showed that it could be used to assay cyclic di-GMP in bacterial lysates. (Image courtesy of Hammond Lab, UC Berkeley)

Newly developed chemiluminescent biosensors shed light on how bacteria function and colonize diverse environments. The Science Cyclic di-GMP (Guanine Monophosphate) is found in nearly all types of bacteria and interacts with cell signaling networks that control many basic cellular functions. It plays an important role in regulating microbial cellulose production and biofilm formation, which affects…

July 2, 2018

A Personal Stamp on the IGB

The signed steel beam upon its return from the JGI. (Paul Mueller)

Beam-Signing Ceremony Collects Signatures for Posterity. On Friday, June 22, JGI Director Nigel Mouncey and Systems Biology Knowledgebase (KBase) CEO/CSO Adam Arkin gathered JGI and KBase staff for a historic ceremony. “The last time we convened together was 18 months ago to break ground,” Mouncey reminded the audience, referring to the January 2017 groundbreaking ceremony…

June 26, 2018

Reproducibility Matters in Large-Scale Maize Study

In the PNAS study, heritable microbes associated with maize roots were identified through a large scale, multi-year, and multi-site field study.

Large scale study identifies core microbial community for maize rhizosphere. A plant’s health is affected not only by conditions such as water and temperature, but by the microorganisms that live around its roots. The rhizosphere microbiome, as this microbial community is known, regulates nutrient availability to the plant from the soil, and can impact plant…

June 13, 2018

Building Sphagnum Genomic Resources

Sphagnum fallax (Image courtesy of Jonathan Shaw, Duke University)

Sphagnome data would enable researchers’ insights on their potential carbon cycling impact. The Science Enabled by the JGI’s Community Science Program (CSP), researchers are developing a number of resources to build up Sphagnum as a plant model system focused on carbon cycling studies, rather than for food or fuel applications. The Impact Sphagnum’s impact on…

May 30, 2018

DAS Tool for Genome Reconstruction from Metagenomes

The Angelo Coast Range Reserve, from which soil samples were taken, protects thousands of acres of the upper watershed of South Fork of the Eel River (shown here) in Mendocino County. (Akos Kokai via Flickr, CC BY 2.0 https://www.flickr.com/photos/on_earth/17307333828/)

Developing and validating an integrated approach to genome recovery from metagenomes. The Science Through the JGI’s Emerging Technologies Opportunity Program (ETOP), researchers have developed and improved upon a tool that combines existing DNA sequence binning algorithms, allowing them to reconstruct more near-complete genomes from soil metagenomes compared to other methods. The Impact Understanding how individual…

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