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Content Tagged "single cell genomics"

Cow rumen metagenome study on PlanetArk

To make sure they found the right microbes in action, they used a cow that had a hole surgically opened right into its rumen. The researchers needed to find the bacteria that worked in airless environments like a cow’s insides.Rubin’s team used metagenomics, a gene-sequencing approach that maps the DNA of a community of organisms… [Read More]

Cow rumen metagenome study on LabSpaces

Rubin’s postdoctoral fellows Matthias Hess and Alex Sczyrba used one of the most promising large-scale bioenergy crops — switchgrass (Panicum virgatum) – and let the cows’ microbial symbionts located in the foregut perform their magic. Read more on LabSpaces [Read More]

Cow rumen metagenome study on PhysOrg

Bovines are thought to have first appeared on the landscape millions of years ago and were domesticated by humans about 10,000 years ago. Rumen microbes evolved to produce molecular machines in the form of enzymes able to efficiently deconstruct plant cell wall polysaccharides such as cellulose and hemicellulose into their constituent small sugar molecules. Another… [Read More]

Cow rumen metagenome study on Reuters

In this case, the goal was to find microbes that make enzymes that can efficiently break down the toughest fibers in switchgrass, a tough crop that can be used to produce ethanol and which can grow in places where food crops do not grow well. But switchgrass is very tough to break down. Read more… [Read More]

Cow rumen metagenome study on MSNBC.com

“Cellulosic ethanol” would use non-food plants such as switchgrass, which is one of the most promising bioenergy crops. But, while advances have been made, it’s still not economically viable.The researchers didn’t come up with the magic mix of enzymes that will most efficiently break down switchgrass and other non-food plants. But they — and the… [Read More]

Cow rumen metagenome study in Scientific American

“If the industry is going to move forward, it’s going to need new enzymes,” says Eddy Rubin, the director of the U.S. Department of Energy’s Joint Genome Institute. Rubin and 16 colleagues report in the January 28 issue of Science how they discovered nearly 30,000 new enzyme candidates by analyzing DNA collected from a cow’s… [Read More]

Cow rumen metagenome study on EurekAlert

“Microbes have evolved over millions of years to efficiently degrade recalcitrant biomass,” said Eddy Rubin, Director of the JGI and a lead on this study. “Communities of these organisms can be found in diverse ecosystems, such as in the rumen of cows, the guts of termites, in compost piles, as well as covering the forest… [Read More]

Cow rumen metagenome study in This Week in Science

Identification of additional enzymes that can degrade cellulose efficiently should help in the development of biofuels on an industrial scale. Uncultured microorganisms living in cow rumen are highly effective at degrading plant cell walls. Hess et al. used metagenomics and single-genome sequencing to assemble draft genomes from microbes adhering to rumen-incubated switchgrass to identify nearly… [Read More]

DOE JGI’s CSP projects in GenomeWeb Daily News

JGI said its action follows the exponential increase of its sequence output in recent years. Just over the past year, the institute’s sequencing output has leapt to 6 terabytes, up from 1 terabyte at the end of the 2009 fiscal year.“We’re really interested in undertaking projects that either require specific upfront molecular biology, very large… [Read More]

Sulcia single-cell genome project in GenomeWeb

In PLoS One this week, researchers at the Department of Energy’s Joint Genome Institute and the University of Arizona report the completed sequence of Candidatus Sulcia meulleri, obtained from an uncultured single cell.  Read more on GenomeWeb. [Read More]